Aiming at the enterprise cooperation in the cluster, on the basis of the AJ model, by introducing the variables of initial cost, innovation coefficient, spillover degree, product similarity coefficient, through the simulation, this article studied the pros and cons of the four cooperative innovation modes which are Complete Cooperation, Semi Cooperative I, Semi Cooperative II, No Cooperation, and analyzed the variables effect on the enterprise income of the four cooperative modes under the cluster environment. At last it discussed the enterprise's proper strategic choice. The study found that the high spillover environment of clusters will weak the motivation of R{\&}D cooperation, corporate earnings increases with the degree of spillover for the first two modes of cooperation and first increases and then decreases for the last two modes. Enterprises with high innovation efficiency should strengthen R{\&}D cooperation while enterprises with high product similarity should strengthen cooperation in production. Cooperative effect will be better to choose cooperative enterprise with homogeneous product.